Ruhr-Universität Bochum

Anatomie und Molekulare Embryologie

Prof. Dr. Dr. h.c. Beate Brand-Saberi

Ruhr-Universität Bochum
Institut für Anatomie
Abteilung für Anatomie und Molekulare Embryologie

RESEARCH The research interests of my group are in the field of developmental biology. We study cell migration, determination and differentiation of mesodermal cells, in particular of precursor cells of skeletal muscle, as well as the physiology of stem cells. Analyses are performed using chicken, zebrafish, mice and human cells. We address questions of intercellular signalling, epigenetic control of gene expression and the activation and function of bHLH transcription factors in cell type specification. Methods: in ovo electroporation, shRNA, In-situ-hybridization, immuno- histochemistry, confocal microscopy, live imaging, transmission electron microscopy, scanning electron microscopy, PCR, Western Blot, Microinjection

Project leader in the EU’s 6th framework programme Netwok of Excellence MYORES Multiorganismic Approach to study normal and aberrant muscle development, function and repair.


Gellisch, M., Wolf, O. T., Minkley, N., Kirchner, W. H., Brüne, M., & Brand-Saberi, B. (2022). Decreased sympathetic cardiovascular influences and hormone-physiological changes in response to Covid-19-related adaptations under different learning environments. Anatomical sciences education, 15(5), 811–826.
Gellisch, M., Morosan-Puopolo, G., Wolf, O. T., Moser, D. A., Zaehres, H., & Brand-Saberi, B. (2023). Interactive teaching enhances students‘ physiological arousal during online learning. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft247, 152050. Advance online publication.

Satya Srirama Karthik Divvela, Patrick Nell, Markus Napirei, Holm Zaehres, Jiayu Chen, Wanda Maria Gerding, Huu Phuc Nguyen, Shaorong Gao and Beate Brand-Saberi (2019). bHLH Transcription Factor Math6 Antagonizes TGF- β Signalling in Reprogramming, Pluripotency and Early Cell Fate Decisions. Cells 8, 529.

Böing M, Brand-Saberi B, Napirei M. (2018). Murine transcription factor Math6 is a regulator of placenta development. SCIENTIFIC REPORTS 8(1), 14997.

Chen A, Li J, Song L, Ji C, Böing M, Chen J, Brand-Saberi B (2017). GGNBP2 is necessary for testis morphology and sperm development. Scientific Reports 7, Article Number: 2998.

Brand-Saberi B, Zaehres H (2016). The development of anatomy: from macroscopic body dissections to stem cell-derived organoids. Histochem Cell Biol. 146 (6), 647-650.

Wang B, Balakrishnan-Renuka A, Napirei M, Theiss C, Brand-Saberi B (2015). Spatiotemporal expression of Math6 during mouse embryonic development. Histochem Cell Biol. 143 (6), 575-582.

Mazur AJ, Morosan-Puopolo G, Makowiecka A, Malicka-Błaszkiewicz M, Nowak D, Brand-Saberi B (2014). Analysis of gelsolin expression pattern in developing chicken embryo reveals high GSN expression level in tissues of neural crest origin. Brain Struct Funct. Doi: 10.1007/s00429-014-0923-5 [Epub ahead of print]

Lever M, Brand-Saberi B, Theiss C. (2014). Neurogenesis, gliogenesis and the developing chicken optic tectum: an immunohistochemical and ultrastructural analysis. Brain Structure and Function 219 (3), 1009-1024.

Morosan-Puopolo G, Balakrishnan-Renuka A, Yusuf F, Chen J, Dai F, Zoidl G, Lüdtke THW, Kispert A, Theiss C, Abdelsabour-Khalaf M, Brand-Saberi B. (2014). Wnt11 Is Required for Oriented Migration of Dermogenic Progenitor Cells from the Dorsomedial Lip of the Avian Dermomyotome. PLOS ONE 9(3): e92679

Pu Q, Abduelmula A, Masyuk M, Theiss C, Schwandulla D, Hans M, Patel K, Brand-Saberi B, Huang R. (2013). The dermomyotome ventrolateral lip is essential for the hypaxial myotome formation. BMC Developmental Biology, 13:37.

Chen J, Dai F, Balakrishnan-Renuka A, Leese F, Schempp W, Schaller F, Hoffmann MM, Morosan-Puopolo G, Yusuf F, Bisschoff IJ, Chankiewitz V, Xue J, Chen J, Ying K, Brand-Saberi, B. (2011) Diversification and molecular evolution of ATOH8, a gene encoding a bHLH transcription factor. PLoS One 6(8):e23005

Rehimi, R., Khalida, N., Yusuf, F., Morosan-Puopolo, G., Brand-Saberi, B. (2010) A novel role of CXCR4 and SDF-1 during migration of cloacal muscle precursors. Dev. Dyn. 239(6):1622-31

Chen,J., Morosan-Puopolo, G., Dai, F. Wang, J., Brand-Saberi, B. (2010) Molecular cloning of chicken Cecr2 and its expression during chicken embryo development. Int.J. Dev Biol. 54(5):925-9

Bonnet A, Dai FP, Brand-Saberi B, Duprez D (2009) Vestigial-like 2 acts downstream of MyoD activation and is associated with skeletal muscle differentiation in chick myogenesis. Mech. Dev. 127(1-2):120-36

Hausott B; Vallant N, Yang L, Dai FP, Brand-Saberi B, Klimaschewski L (2009) Sprouty2 down-regulation promotes peripheral axon regeneration by adult sensory neurons in vitro. MCN 42(4):328-40

Zhao W., Dai F., Bonafede A., Schäfer S., Jung M., Gamel A.J.,Yusuf F., Wang J., Brand-Saberi B. (2009) Histone deacetylase inhibitor, Trichostatin A, affects gene expression patterns during morphogenesis of chick limb buds in vivo. Cells Tissues Organs 190:121-134

Rehimi R., Yusuf F., Dai F., Morosan-Puopolo G., Brand-Saberi B. (2008) Stromal-derived factor-1 alpha (SDF-1a) expression during early chick development. Int. J. Dev. Biol. 52:87-92

Bonafede, A., Köhler, T, Rodriguez-Niedenführ, M., Brand-Saberi, B. (2006) BMPs restrict the position of premuscle masses in the limb buds by influencing Tcf4 expression. Dev. Biol. 299:330-344

Yusuf, F. Rehimi, R., Morosan-Puopolo, G., Dai, F., Zhang, X., Brand-Saberi, B. (2006) Inhibitors of CXCR4 affect the migration and fate of CXCR4+ progenitors in the developing limb of chick embryos. Dev. Dyn. 235:3007-15

Weise C, Dai F, Pröls F, Ketelsen UP, Dohrmann U, Kirsch M, Brand-Saberi B. (2006) Myogenin (Myf4) upregulation in trans-differentiating fibroblasts from a congenital myopathy with arrest of myogenesis and defects of myotube formation. Anat. Embryol. 211: 639-648

Zhang, X., Dai, F., Weise, C., Yusuf, F., Bonafede, A., Morosan-Puopolo, G. Rehimi, R., Wang, J., Brand-Saberi , B. (2006) Expression of the avian Nucleolar complex associated protein2 (NOC2) – homologue in embryonic development. Anat. Embryol. 211: 649-658

Larsen, K.C., Füchtbauer, E.M., Brand-Saberi, B. (2006) The neural tube is required to maintain primary segmentation in the sclerotome. Cells Tissues Organs 182:12-21.

Vasyutina, E., Stebler, J., Brand-Saberi, B., Schulz, S., Raz, E., Birchmeier C. (2005) CXCR4 and Gab1 co-operate to control the development of migrating muscle progenitor cells. Genes and Development 19: 2187-2198.

Dai, F.P., Yusuf, F., Farjah, G.H., Brand-Saberi, B. (2005) pEGFP-vector based RNA interference for in vivo gene functional analysis in chicken embryos. Dev. Biol. 285: 80-90

Yusuf, F., Rehimi, R., Dai, F.P., Brand-Saberi, B. (2005) The expression pattern of the chemokine receptor CXCR4 in chick embryo development. Anat. Embryol. 210:35-41

Adham, I.M., Gille, M., Gamel, A.J., Reis, A., Dressel, R., Steding, G., Brand-Saberi, B., Engel, W.(2005) Pathological and genetic analysis of the scoliosis (sco) mouse: a new allele of Pax-1. Cytogenet Genome Res 111: 16-26

Ketelsen, U.P., Brand-Saberi, B., Uhlenberg, B., Wagner, M., Laberke H.G., Omran, H. Congenital myopathy with arrest of myogenesis prior fusion of myoblasts to myotubes. Neuropediatrics 36: 1-6 (2005)

Köhler, T., Pröls, F., Brand-Saberi, B. (2005) PCNA In situ hybridization: A novel and reliable tool for detection of dynamic changes in proliferative activity. Histochemistry and Cell Biology 123:315-27.

Hornik, C., Krishan, K., Yusuf, F., Scaal, M., Brand-Saberi, B. (2005) cDermo-1 misexpression induces dense dermis, feathers and scales. Dev. Biol. 277:42-50

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