
DR. MARKUS NAPIREI
Ruhr-Universität Bochum
Institut für Anatomie
Abteilung für Anatomie und Molekulare Embryologie
- Tel: +49 (0)234 32 23164
- cell death (apoptosis versus necrosis) in vitro and in vivo
- physiological functions of extracellular deoxyribonucleases
- biochemical properties of deoxyribonucleases
- anti-nuclear autoimmunity (Systemic Lupus Erythematosus)
- disposal of dying cells in vivo
- cell culture
- transgenic mice
- microscopy
- histology
- enzymology
- molecular genetics
- molecular biology
2006 – 2007 Funding by the FoRUM-program at the Ruhr-University Bochum
2001 Graduation prize of the Knoll AG awarded by the Gesellschaft für Biochemie und Molekularbiologie
2000 Scholarship of the Novartis-Stiftung für therapeutische Forschung
1997 – 2004 Funding by the Deutsche Forschungsgemeinschaft
SELECTED PUBLICATIONS
Napirei M., Mannherz H. G. (2009) Molecules involved in recognition and clearance of apoptotic/necrotic cells and cell debris. In Phagocytosis of dying cells: From molecular mechanisms to human disease (Krysko, D. V. and Vandenabeele, P., eds.). pp. 103-145, Springer Verlag
Napirei M., Ludwig S., Mezrhab J., Klöckl T., Mannherz H. G. (2009) Murine serum nucleases-contrasting effects of plasmin and heparin on the activities of DNase1 and DNase1-like 3 (DNase1l3). FEBS J., 276, 1059-1073
Ludwig S., Mannherz H. G., Schmitt S., Schäffer M., Zentgraf H., Napirei M. (2009) Murine serum deoxyribonuclease 1 (Dnase1) activity partly originates from the liver. Int. J. Biochem. Cell Biol., 41, 1079-1093
Jacob M., Mannherz H. G., Napirei M. (2007) Chromatin breakdown by deoxyribonuclease1 promotes acetaminophen-induced liver necrosis: an ultrastructural and histochemical study on male CD-1 mice. Histochem. Cell Biol., 128, 19-33
Napirei M., Gültekin A., Klöckl T., Möröy T., Frostegard J., Mannherz H. G. (2006) Systemic lupus-erythematosus: Deoxyribonuclease 1 in necrotic chromatin disposal. Int. J. Biochem. Cell Biol., 38, 297-306
Napirei M., Basnakian A. G., Apostolov E. O., Mannherz H. G. (2006) Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice. Hepatology, 43, 297-305
Napirei M., Wulf S., Eulitz D., Mannherz H. G., Klöckl T. (2005) Comparative characterization of rat deoxyribonuclease 1 (Dnase1) and murine deoxyribonuclease 1-like 3 (Dnase1l3). Biochem. J., 389, 355-364
Napirei M., Wulf S., Mannherz H. G. (2004) Chromatin breakdown during necrosis by serum Dnase1 and the plasminogen system. Arthritis Rheum., 50, 1873-1883
Napirei M., Ricken A., Eulitz D., Knoop H., Mannherz H. G. (2004) Expression pattern of the Deoxyribonuclease 1 gene: lessons from the Dnase1 knockout mouse. Biochem J., 380, 929-937
Jacob M., Napirei M., Ricken A., Dixkens C., Mannherz H. G. (2002) Histopathology of lupus-like nephritis in Dnase1-deficient mice in comparison to NZB/W F1 mice. Lupus, 11, 514-527
Napirei M., Karsunky H., Zevnik B., Stephan H., Mannherz H. G., Möröy, T. (2000) Features of systemic lupus erythematosus in Dnase1-deficient mice. Nat. Genet., 25, 177-181